Online Gamers as Scientists

If you thought that online gamers were just a load of geeks, incapable of socializing with the outside world, and living within the confines of their own in their bedrooms, you might like to have a look this website called Foldit. Foldit is a game, but its aim is to solve puzzles for science, and players have recently made some remarkable inroads into the world of protein modelling. Below is a model of an Amino Acid, and it is this type of thing that gamers manipulate.
An Amino Acid Protein MoleculeThis article that explains the process is in the online journal Nature, Structure and Molecular Biology, and begins with the following statement:

“Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.”

The fold it game has existed for a couple of years now. Players create protein structures, with the most stable and low energy structures scoring the most points.

The gamers in general are not scientists and they manually manipulate the model from a base form that is provided to them at the start of the operation. They have a variety of tools but the most important thing is that they have better spatial reasoning skills than computers. Computer models had tried to solve the problem cited above for 10 years without success, gamers produced an adequate model that was then refined by scientists in just 3 weeks.

We could draw similarities to citizen science, having seen posts on this blog discussing loaning out some of your computer’s spare hard disk space and memory to solve scientific problems, and the now common use of similar set ups in astronomy.

Just this week the Astronomy and Telescope journal is entitled Citizen Science, and addresses the issue of amateurs classifying high definition photos of far off galaxies. They say that it is the future of astronomic discovery. See my post on The Bassetti Foundation website for a lay explanation.

The gaming process is an interesting innovation though, as it uses skills that may not be particularly associated with science, but reveal themselves to be extremely important.

Search engines are changing the way our memory works

A recent article in Science Mag suggests that the use of computers and the internet might actually be changing the way our memory works.

A series of psychology experiments recently carried out have shown that sometimes, when people were presented with hard to answer questions, they began to think of computers.

If participants believed that it would be easy to find answers on Google later, then they had poorer recall of the actual answer, and yet a greater memory of where the answer was stored.

A head x-ray showing someone with a computer for a brainThe researchers said that the internet acts as a tool which we now depend upon to to aid our memories, by remembering some data for us.

Here is the abstract for the journal entry

The advent of the Internet, with sophisticated algorithmic search engines, has made accessing information as easy as lifting a finger. No longer do we have to make costly efforts to find the things we want. We can “Google” the old classmate, find articles online, or look up the actor who was on the tip of our tongue. The results of four studies suggest that when faced with difficult questions, people are primed to think about computers and that when people expect to have future access to information, they have lower rates of recall of the information itself and enhanced recall instead for where to access it. The Internet has become a primary form of external or transactive memory, where information is stored collectively outside ourselves.

In more simplified English, what this is basically saying is that it is now much easier to access data online, mainly thanks to search engines like Google, Bing and Yahoo. If we have a question, we can find the answer in seconds.


This has lead the the human brain associating the thought of a problem with computers, as it believes that the internet will be the source of the solution. Search engines are now embeded so much in our brain, that when we think of a problem, we no longer bother trying to work out the answer for ourselves, but instead we associate the possibility of finding the solution of the problem with a search engine.

Let’s be honest, who hasn’t been bugged by something, asked someone else who also wasn’t able to help and as a result was either told “Google it” or thought “I could Google that”? I have, in fact I would say it happens on a weekly basis!

Question time

So what do you think? Are computers, the internet and search engines making us stupid, or is it just that we are now adapting as a race to more efficient ways of finding out information?